BDBM525925 (S)-3-chloro-4-((1-phenylpropyl)amino)-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide::US11174268, Example 32

SMILES CC[C@H](Nc1ccc(cc1Cl)S(=O)(=O)Nc1ncns1)c1ccccc1

InChI Key InChIKey=RHNBRBMVSWEKPZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 525925   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525925((S)-3-chloro-4-((1-phenylpropyl)amino)-N-(1,2,4-th...)
Affinity DataIC50: 92nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525925((S)-3-chloro-4-((1-phenylpropyl)amino)-N-(1,2,4-th...)
Affinity DataIC50: 23nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525925((S)-3-chloro-4-((1-phenylpropyl)amino)-N-(1,2,4-th...)
Affinity DataIC50: 1.28E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525925((S)-3-chloro-4-((1-phenylpropyl)amino)-N-(1,2,4-th...)
Affinity DataIC50: 1.06E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent