BDBM525902 Synthesis of(S)-3-chloro-2-fluoro-4-((1-(2-fluorophenyl)ethyl)amino)-N-(thiazol-2-yl)benzenesulfonamide::US11174268, Example 9

SMILES C[C@H](Nc1ccc(c(F)c1Cl)S(=O)(=O)Nc1nccs1)c1ccccc1F

InChI Key InChIKey=HSMFEMBCNVTKQG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 525902   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525902(Synthesis of(S)-3-chloro-2-fluoro-4-((1-(2-fluorop...)
Affinity DataIC50: 181nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525902(Synthesis of(S)-3-chloro-2-fluoro-4-((1-(2-fluorop...)
Affinity DataIC50: 26nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525902(Synthesis of(S)-3-chloro-2-fluoro-4-((1-(2-fluorop...)
Affinity DataIC50: 4.22E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525902(Synthesis of(S)-3-chloro-2-fluoro-4-((1-(2-fluorop...)
Affinity DataIC50: 2.36E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525902(Synthesis of(S)-3-chloro-2-fluoro-4-((1-(2-fluorop...)
Affinity DataIC50: 4.34E+3nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent