BDBM525570 (S)-5-(1-(6-(2-(2- hydroxypropan-2- yl)morpholino)pyrimidin-4- yl)-1H-indazol-6- yl)spiro[2.3]hexane-5- carbonitrile::US11174248, Example 43

SMILES CC(C)(O)[C@@H]1CN(CCO1)c1cc(ncn1)-n1ncc2ccc(cc12)C1(CC2(CC2)C1)C#N

InChI Key InChIKey=IBBZAFDPAUVUTA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 525570   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM525570((S)-5-(1-(6-(2-(2- hydroxypropan-2- yl)morpholino)...)
Affinity DataIC50: 0.900nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent