BDBM525566 5-(1-(6-(8-methyl-5-oxa- 2,8- diazaspiro[3.5]nonan-2- yl)pyrimidin-4-yl)-1H- indazol-6- yl)spiro[2.3]hexane-5- carbonitrile::US11174248, Example 28

SMILES CN1CCOC2(CN(C2)c2cc(ncn2)-n2ncc3ccc(cc23)C2(CC3(CC3)C2)C#N)C1

InChI Key InChIKey=BLAGDQSVTHEJBI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 525566   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM525566(5-(1-(6-(8-methyl-5-oxa- 2,8- diazaspiro[3.5]nonan...)
Affinity DataIC50: 1.30nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
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