BDBM525559 (S)-5-(1-(2- (methoxymethyl)-6-(3- methyl-4-(oxetan-3- yl)piperazin-1- yl)pyrimidin-4-yl)-1H- indazol-6- yl)spiro[2.3]hexane-5- carbonitrile::US11174248, Example 21

SMILES COCc1nc(cc(n1)-n1ncc2ccc(cc12)C1(CC2(CC2)C1)C#N)N1CCN(C2COC2)[C@@H](C)C1

InChI Key InChIKey=PGFSZAGYPVQMQH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 525559   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM525559((S)-5-(1-(2- (methoxymethyl)-6-(3- methyl-4-(oxeta...)
Affinity DataIC50: 10.9nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
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