BDBM525556 5-(1-(6-(4-(2- hydroxypropan-2-yl)-2- azabicyclo[2.1.1]hexan- 2-yl)pyrimidin-4-yl)-1H- pyrazolo[4,3-c]pyridin-6- yl)spiro[2.3]hexane-5- carbonitrile::US11174248, Example 18

SMILES CC(C)(O)C12CC(C1)N(C2)c1cc(ncn1)-n1ncc2cnc(cc12)C1(CC2(CC2)C1)C#N

InChI Key InChIKey=BSVOOYWJONDZHB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 525556   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM525556(5-(1-(6-(4-(2- hydroxypropan-2-yl)-2- azabicyclo[2...)
Affinity DataIC50: 19.2nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
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