BDBM525552 (S)-5-(1-(6-(2-(hydroxy- methyl)morpholino) pyrimidin-4-yl)-1H- indazol-6- yl)spiro[2.3]hexane-5- carbonitrile::US11174248, Example 14

SMILES OC[C@@H]1CN(CCO1)c1cc(ncn1)-n1ncc2ccc(cc12)C1(CC2(CC2)C1)C#N

InChI Key InChIKey=VLSXCPLLXINUOK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 525552   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM525552((S)-5-(1-(6-(2-(hydroxy- methyl)morpholino) pyrimi...)
Affinity DataIC50: 2.90nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
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