BDBM525052 US11168102, Example 8-1.

SMILES C[C@@H](Nc1ncnc2n(C)c(=O)c(cc12)C1CN(C)CCO1)c1cccc(C(F)F)c1F

InChI Key InChIKey=JWROZZFQXPMLLJ-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 525052   

TargetSon of sevenless homolog 1 [564-1049]()
Revolution Medicines

US Patent
LigandPNGBDBM525052(US11168102, Example 8-1.)
Affinity DataKd:  24.2nMAssay Description:The purpose of this assay was to characterize the inhibitory activity of compounds on SOS1 nucleotide exchange of KRAS. Data was reported as IC50 val...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1 [564-1049]()
Revolution Medicines

US Patent
LigandPNGBDBM525052(US11168102, Example 8-1.)
Affinity DataIC50: 24.6nMAssay Description:Using a GE Biacore 8K SPR instrument, avi-tagged SOS1 catalytic domain protein was immobilized to a level of approximately 6000 response units (RU) o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent