BDBM524922 BDBM50521256::US11168095, Example 163

SMILES Brc1cccc2c1OC\C=C\Cn1cnnc1-c1cccc(NC2=O)n1

InChI Key InChIKey=KOQWJESDFRBKBX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 524922   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM524922(US11168095, Example 163 | BDBM50521256)
Affinity DataIC50: 100nMAssay Description:Inhibition of full-length human GST-tagged ASK1 expressed in baculovirus expression system using biotinylated STK Substrate 3 preincubated for 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM524922(US11168095, Example 163 | BDBM50521256)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant V5-tagged ASK1 (unknown origin) expressed in HEK293 cells assessed as reduction in ASK1 autophosphorylation at T838 residue...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM524922(US11168095, Example 163 | BDBM50521256)
Affinity DataIC50: 550nMAssay Description:Table 1: Briefly, 20 μL aliquots of a 1.5× stock of ASK1, STK Substrate 3 and Assay Buffer were distributed in the wells of a white 384 well Opt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent