BDBM524658 US11168090, Example 102::US11851434, Example 102

SMILES Cn1cc(cn1)-c1cn2ncc(C#N)c2c(n1)-c1ccc(nc1)N1CCC(O)(Cc2ccccn2)CC1

InChI Key InChIKey=CMHPACQSVFAWIA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 524658   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM524658(US11168090, Example 102 | US11851434, Example 102)
Affinity DataIC50: 7.20nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

LigandPNGBDBM524658(US11168090, Example 102 | US11851434, Example 102)
Affinity DataIC50: 20.1nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM524658(US11168090, Example 102 | US11851434, Example 102)
Affinity DataIC50: 7.20nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2024
Entry Details
Go to US Patent

LigandPNGBDBM524658(US11168090, Example 102 | US11851434, Example 102)
Affinity DataIC50: 20.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2024
Entry Details
Go to US Patent