BDBM524633 US11168090, Example 77::US11851434, Example 77

SMILES CN(C)C(C(=O)N1CCN(CC1)c1ccc(cn1)-c1nc(cn2ncc(C#N)c12)-c1cnn(C)c1)c1ccc(Cl)cc1

InChI Key InChIKey=SMCAJKJZVOKVBQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 524633   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM524633(US11168090, Example 77 | US11851434, Example 77)
Affinity DataIC50: 9.30nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

LigandPNGBDBM524633(US11168090, Example 77 | US11851434, Example 77)
Affinity DataIC50: 46.6nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM524633(US11168090, Example 77 | US11851434, Example 77)
Affinity DataIC50: 9.30nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2024
Entry Details
Go to US Patent

LigandPNGBDBM524633(US11168090, Example 77 | US11851434, Example 77)
Affinity DataIC50: 46.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2024
Entry Details
Go to US Patent