BDBM524576 US11168090, Example 18::US11851434, Example 18

SMILES CC(C)CNC(=O)N1CCN(CC1)c1ccc(cn1)-c1nc(cn2ncc(C#N)c12)-c1cnn(C)c1

InChI Key InChIKey=WXJJXWVEIWEAOZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 524576   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM524576(US11168090, Example 18 | US11851434, Example 18)
Affinity DataIC50: 10.7nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

LigandPNGBDBM524576(US11168090, Example 18 | US11851434, Example 18)
Affinity DataIC50: 56.7nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM524576(US11168090, Example 18 | US11851434, Example 18)
Affinity DataIC50: 10.7nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2024
Entry Details
Go to US Patent

LigandPNGBDBM524576(US11168090, Example 18 | US11851434, Example 18)
Affinity DataIC50: 56.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/15/2024
Entry Details
Go to US Patent