BDBM524540 US11168089, Ex. No. 16::US11873304, Example 16::US20250041310, Compound 8

SMILES CN1CCC(NCc2cccc(F)c2C(O)c2nc3cc(nc(N)n3n2)-c2cccc(C#N)c2F)C1=O

InChI Key InChIKey=FYICDFUJPPPZCX-UHFFFAOYSA-N

Data  3 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 524540   

TargetAdenosine receptor A2b(Human)
Incyte

US Patent
LigandPNGBDBM524540(US11168089, Ex. No. 16 | US11873304, Example 16 | ...)
Affinity DataEC50:  55nMAssay Description:Assays are conducted in deep well polypropylene plates (Greiner 786201) in a final volume of 550 μL. Test compounds are first serially diluted i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
Incyte

US Patent
LigandPNGBDBM524540(US11168089, Ex. No. 16 | US11873304, Example 16 | ...)
Affinity DataKi: <10nMAssay Description:Assays were conducted in black low volume 384-well polystyrene plates (Greiner 784076-25) in a final volume of 10 μL. Test compounds were first ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
Incyte

US Patent
LigandPNGBDBM524540(US11168089, Ex. No. 16 | US11873304, Example 16 | ...)
Affinity DataKi: <10nMAssay Description:Assays were conducted in black low volume 384-well polystyrene plates (Greiner 784076-25) in a final volume of 10 μL. Test compounds were first ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent

TargetAdenosine receptor A2a(Human)
Incyte

US Patent
LigandPNGBDBM524540(US11168089, Ex. No. 16 | US11873304, Example 16 | ...)
Affinity DataKi: <10nMAssay Description:Assays were conducted in black low volume 384-well polystyrene plates (Greiner 784076-25) in a final volume of 10 μL. Test compounds were first seria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2025
Entry Details
Go to US Patent