BDBM524414 2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyridine-2- carbonyl)pyrrolidin-2-yl)-N-((R)-6- guanidino-1-(methylamino)-1- oxohexan-2-yl)thiazole-4-carboxamide::US11168083, Example 12::US11168083, Example 57

SMILES CNC(=O)[C@@H](CCCCNC(N)=N)NC(=O)c1csc(n1)[C@@H]1C[C@@H](N)CN1C(=O)c1cn2cc(Cl)ccc2n1

InChI Key InChIKey=LLPPLVKHKYCFMU-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 524414   

TargetPlasma kallikrein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524414(US11168083, Example 57 | 2-((2S,4R)-4-amino-1-(6- ...)
Affinity DataEC50: <100nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetPlasma kallikrein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524414(US11168083, Example 57 | 2-((2S,4R)-4-amino-1-(6- ...)
Affinity DataEC50:  3.00E+3nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent