BDBM524403 2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyridine-2- carbonyl)pyrrolidin-2-yl)-N-((7- chloroimidazo[1,5-a]pyridin-1- yl)methyl)thiazole-4-carboxamide::US11168083, Example 55

SMILES N[C@@H]1C[C@H](N(C1)C(=O)c1cn2cc(Cl)ccc2n1)c1nc(cs1)C(=O)NCc1ncn2ccc(Cl)cc12

InChI Key InChIKey=FKQMDAAKAOWPEB-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 524403   

TargetPlasma kallikrein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524403(2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyrid...)
Affinity DataEC50:  15nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetCoagulation factor X(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524403(2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyrid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetProthrombin(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524403(2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyrid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetNeutrophil elastase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524403(2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyrid...)
Affinity DataIC50: 1.00E+4nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSerine protease 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524403(2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyrid...)
Affinity DataIC50: 1.00E+5nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524403(2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyrid...)
Affinity DataEC50:  550nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent