BDBM524402 US11168083, Example 33

SMILES CNC(=O)[C@H](CCCCNC(N)=N)NC(=O)c1csc(n1)[C@@H]1CCCN1C(=O)c1cn2cc(Cl)ccc2n1

InChI Key InChIKey=JYHRVUUCZYFFGN-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 524402   

TargetPlasma kallikrein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524402(US11168083, Example 33)
Affinity DataEC50:  3.24E+3nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetCoagulation factor X(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524402(US11168083, Example 33)
Affinity DataIC50: 1.00E+4nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetProthrombin(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524402(US11168083, Example 33)
Affinity DataIC50: 1.00E+4nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetNeutrophil elastase(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524402(US11168083, Example 33)
Affinity DataIC50: 1.00E+4nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSerine protease 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524402(US11168083, Example 33)
Affinity DataIC50: 1.00E+5nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524402(US11168083, Example 33)
Affinity DataEC50:  3.00E+3nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent