BDBM523882 (S)-5-(4-Cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-(6-(5-vinyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)pyridin-2-yl)benzamide::US11136324, Example 37

SMILES Cc1cc(F)c(cc1-n1cnc(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnc2CC[C@@H](C=C)n12

InChI Key InChIKey=IFTHQZYTXKIHJQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 523882   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangsu Hansoh Pharmaceutical Group

US Patent
LigandPNGBDBM523882(US11136324, Example 37 | (S)-5-(4-Cyclopropyl-1H-i...)
Affinity DataIC50: 3.5nMAssay Description:In this test, the fluorescence-resonance energy transfer (TR-FRET) method was used to determine the inhibition effect of the test compounds on ASK1 k...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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