BDBM522988 1-(4-(4-amino-7- cyclopropyl-7H- pyrrolo[2,3- d]pyrimidin-5-yl)-3- fluorophenyl)-3-(3-(1- (trifluoromethyl)cyclopropyl)isoxazol- 5-yl)urea::US11161852, Compound 11::US11713321, Example 11

SMILES Nc1ncnc2n(cc(-c3ccc(NC(=O)Nc4cc(no4)C4(CC4)C(F)(F)F)cc3F)c12)C1CC1

InChI Key InChIKey=FOTMEQIWZWXRLT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522988   

TargetSerine/threonine-protein kinase Nek7(Human)
Halia Therapeutics

US Patent
LigandPNGBDBM522988(US11161852, Compound 11 | 1-(4-(4-amino-7- cyclopr...)
Affinity DataIC50: 400nMAssay Description:Casein substrate (from bovine milk, hydrolyzed and partially dephosphorylated mixture of α, β and a caseins, obtained from Sigma Aldrich, c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Nek7(Human)
Halia Therapeutics

US Patent
LigandPNGBDBM522988(US11161852, Compound 11 | 1-(4-(4-amino-7- cyclopr...)
Affinity DataIC50: 400nMAssay Description:Casein substrate (from bovine milk, hydrolyzed and partially dephosphorylated mixture of α, β and κ caseins, obtained from Sigma Aldri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
Go to US Patent