BDBM522435 1-(4,4-difluoro-1- methylpyrrolidin-3-yl)-2-(3- fluorocyclopentyl)-1H- imidazo[-c]quinolin-8- carbonitrile, DIAST A::US11161844, Example 57::US11161844, Example 58::US11161844, Example 59::US11161844, Example 60::US11161844, Example 61::US11161844, Example 62::US11161844, Example 63::US11161844, Example 64

SMILES CN1CC(n2c(nc3cnc4ccc(cc4c23)C#N)C2CCC(F)C2)C(F)(F)C1

InChI Key InChIKey=IMXLFVISBPYHPR-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 522435   

LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 4.54nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 5.94nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 12.2nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 21.2nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 30.5nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 141nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 57.1nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 97.4nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 464nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 3.00E+3nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 1.84E+3nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522435(US11161844, Example 64 | US11161844, Example 62 | ...)
Affinity DataIC50: 2.30E+3nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent