BDBM522421 8-fluoro-2-[trans-3- fluroocyclopentyl]-1- [(2R,4R)-2-methyl- tetrahydro-2H-pyran-4-yl]- 1H-imidazo[-c]quinoline, DIAST 13::US11161844, Example 37::US11161844, Example 38::US11161844, Example 43

SMILES C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(F)cc3c12)C1CCC(F)C1

InChI Key InChIKey=BYBVLCDFEBESJW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 522421   

LigandPNGBDBM522421(US11161844, Example 43 | 8-fluoro-2-[trans-3- flur...)
Affinity DataIC50: 200nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent

LigandPNGBDBM522421(US11161844, Example 43 | 8-fluoro-2-[trans-3- flur...)
Affinity DataIC50: 202nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent

LigandPNGBDBM522421(US11161844, Example 43 | 8-fluoro-2-[trans-3- flur...)
Affinity DataIC50: 5.68nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent