BDBM522397 2-[(cis)-3-fluorocyclopentyl]-1-[(2R,4R)-2-methyltetrahydro-2H-pyran-4-yl]-1H-imidazo[-c]quinoline-8-carbonitrile, ENT 1::US11161844, Example 13

SMILES C[C@@H]1C[C@@H](CCO1)n1c(nc2cnc3ccc(cc3c12)C#N)[C@H]1CC[C@@H](F)C1

InChI Key InChIKey=VCGRRVBPZIYWRD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522397   

LigandPNGBDBM522397(US11161844, Example 13 | 2-[(cis)-3-fluorocyclopen...)
Affinity DataIC50: 6.29nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522397(US11161844, Example 13 | 2-[(cis)-3-fluorocyclopen...)
Affinity DataIC50: 3.84nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent