BDBM522392 8-chloro-2-(4,4-difluorocyclohexyl)-1-[(2R,4R)-2-methyltetrahydro-2H-pyran-4-yl]-1H-imidazo[-c]quinoline::US11161844, Example 8

SMILES C[C@@H]1CC(CCO1)n1c(nc2cnc3ccc(Cl)cc3c12)C1CCC(F)(F)CC1

InChI Key InChIKey=FMJXDKFGYNPFHX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522392   

LigandPNGBDBM522392(US11161844, Example 8 | 8-chloro-2-(4,4-difluorocy...)
Affinity DataIC50: 15.9nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522392(US11161844, Example 8 | 8-chloro-2-(4,4-difluorocy...)
Affinity DataIC50: 12.1nMAssay Description:LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat #PV4874) was incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent