BDBM522286 US11161839, Example 10g

SMILES C[C@H](c1ncccn1)NC2=CC(=O)N(c3c2cc(cc3)Nc4ccnc(c4C#N)Cl)C

InChI Key InChIKey=NZWNGZWURJFQPT-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522286   

TargetB-cell lymphoma 6 protein [5-129](Human)
The Institute of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM522286(US11161839, Example 10g)
Affinity DataIC50: 79.4nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained either 1 nM (data in table 1b) or 10 nM (data in table 1a) Trx-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM522286(US11161839, Example 10g)
Affinity DataIC50: 82nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)