BDBM522193 (S)-5-(5-Amino-6-(1H-pyrazol-4- yl)pyrazin-2-yl)-2-(1- cyclopropylethyl)-7- (methylsulfonyl)isoindolin-1-one, trifluoroacetate salt::US11161838, Example 11

SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1cnc(N)c(n1)-c1cn[nH]c1

InChI Key InChIKey=HARQYXZVKDQKIZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522193   

LigandPNGBDBM522193((S)-5-(5-Amino-6-(1H-pyrazol-4- yl)pyrazin-2-yl)-2...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent

LigandPNGBDBM522193((S)-5-(5-Amino-6-(1H-pyrazol-4- yl)pyrazin-2-yl)-2...)
Affinity DataIC50: 2.00E+3nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent