BDBM522190 (S)-5-(5-Amino-6-(1-methyl-1H- pyrazol-4-yl)pyrazin-2-yl)-2-(1- cyclopropylethyl)-7- (methylsulfonyl)isoindolin-1-one, trifluoroacetate salt::US11161838, Example 8

SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1cnc(N)c(n1)-c1cnn(C)c1

InChI Key InChIKey=VFQBUURGDXGRNW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 522190   

LigandPNGBDBM522190((S)-5-(5-Amino-6-(1-methyl-1H- pyrazol-4-yl)pyrazi...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
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LigandPNGBDBM522190((S)-5-(5-Amino-6-(1-methyl-1H- pyrazol-4-yl)pyrazi...)
Affinity DataIC50: 2.00E+3nMAssay Description:The kinase reaction was conducted in polystyrene 384-well Greiner Bio-one white plate from Thermo Fisher Scientific in a final volume of 25 μL. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
Go to US Patent