BDBM521999 N-[3-[6-(difluoromethoxy)- 3,4-dihydro-2H-1,4- benzoxazin-7-yl]-1-methyl- pyrazol-4-yl]pyrazolo[1,5- a]pyrimidine-3-carboxamide::US11155557, Example 89

SMILES Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc2OCCNc2cc1OC(F)F

InChI Key InChIKey=AKKMNVYVOCEDET-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 521999   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM521999(US11155557, Example 89 | N-[3-[6-(difluoromethoxy)...)
Affinity DataKi:  0.100nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM521999(US11155557, Example 89 | N-[3-[6-(difluoromethoxy)...)
Affinity DataKi:  0.120nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent