BDBM521289 9-fluoro-5-[4- [(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]-4- (1H-indol-5-yl)- 2,3-dihydro-1- benzoxepin-8- ol::US11149031, Example 113

SMILES Oc1ccc2c(OCCC(c3ccc4[nH]ccc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F

InChI Key InChIKey=BODULLXGJUPELE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521289   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandPNGBDBM521289(9-fluoro-5-[4- [(3S)-1-(3- fluoropropyl)pyr- rolid...)
Affinity DataIC50: 6nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM521289(9-fluoro-5-[4- [(3S)-1-(3- fluoropropyl)pyr- rolid...)
Affinity DataIC50: 19nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent

TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandPNGBDBM521289(9-fluoro-5-[4- [(3S)-1-(3- fluoropropyl)pyr- rolid...)
Affinity DataIC50: 32nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
US Patent