BDBM521273 4-(4-chloro-3- fluoro-phenyl)- 5-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]- 2,3-dihydro-1- benzoxepin-8- ol::US11149031, Example 97

SMILES Oc1ccc2c(OCCC(c3ccc(Cl)c(F)c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1

InChI Key InChIKey=CBLNYKMJBYYDKM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521273   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandPNGBDBM521273(4-(4-chloro-3- fluoro-phenyl)- 5-[4-[(3S)-1-(3- fl...)
Affinity DataIC50: 50nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandPNGBDBM521273(4-(4-chloro-3- fluoro-phenyl)- 5-[4-[(3S)-1-(3- fl...)
Affinity DataIC50: 358nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM521273(4-(4-chloro-3- fluoro-phenyl)- 5-[4-[(3S)-1-(3- fl...)
Affinity DataIC50: 18nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent