BDBM521197 3-(2,4- dichlorophenyl)- 4-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]oxyphenyl]- 2H- thiochromen-7- ol::US11149031, Example 21

SMILES Oc1ccc2C(=C(CSc2c1)c1ccc(Cl)cc1Cl)c1ccc(O[C@H]2CCN(CCCF)C2)cc1

InChI Key InChIKey=GDZXJOBNEJJTCY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521197   

TargetEstrogen receptor [298-554](Human)
Sanofi

US Patent
LigandPNGBDBM521197(3-(2,4- dichlorophenyl)- 4-[4-[(3S)-1-(3- fluoropr...)
Affinity DataIC50: 9nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetEstrogen receptor [298-554,D538G](Human)
Sanofi

US Patent
LigandPNGBDBM521197(3-(2,4- dichlorophenyl)- 4-[4-[(3S)-1-(3- fluoropr...)
Affinity DataIC50: 47nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetEstrogen receptor [298-554,Y537S](Human)
Sanofi

US Patent
LigandPNGBDBM521197(3-(2,4- dichlorophenyl)- 4-[4-[(3S)-1-(3- fluoropr...)
Affinity DataIC50: 19nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreen TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent