BDBM521084 6-(2-chloro-5-fluoro-phenyl)-N-[[7- (tetrahydropyran-4-ylmethyl)-7- azaspiro[3.5]nonan-2- yl]methyl]pyridazin-3-amine::US11149022, Cpd. No. 44

SMILES Fc1ccc(Cl)c(c1)-c1ccc(NCC2CC3(C2)CCN(CC2CCOCC2)CC3)nn1

InChI Key InChIKey=MKHOTMVHFYJIAH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521084   

TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM521084(US11149022, Cpd. No. 44 | 6-(2-chloro-5-fluoro-phe...)
Affinity DataIC50: 730nMAssay Description:For high throughput measurement of agonist-evoked increases in intracellular calcium, CHO-K1 cells stably expressing muscarinic receptors were plated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM521084(US11149022, Cpd. No. 44 | 6-(2-chloro-5-fluoro-phe...)
Affinity DataIC50: 724nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM521084(US11149022, Cpd. No. 44 | 6-(2-chloro-5-fluoro-phe...)
Affinity DataIC50: 730nMAssay Description:Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed