BDBM521047 N,N-dimethyl-5-(naphthalen-1-yl)-6-(pyridin-4-yl)pyrazin-2-amine::US11149020, Compound 44 (MW-064)

SMILES CN(C)c1cnc(-c2cccc3ccccc23)c(n1)-c1ccncc1

InChI Key InChIKey=CDYRUKWQQPYHTN-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 521047   

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM521047(N,N-dimethyl-5-(naphthalen-1-yl)-6-(pyridin-4-yl)p...)
Affinity DataIC50: 456nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetCasein kinase I isoform delta(Human)
Columbia University

US Patent
LigandPNGBDBM521047(N,N-dimethyl-5-(naphthalen-1-yl)-6-(pyridin-4-yl)p...)
Affinity DataIC50: 1.00E+4nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 14(Human)
Columbia University

US Patent
LigandPNGBDBM521047(N,N-dimethyl-5-(naphthalen-1-yl)-6-(pyridin-4-yl)p...)
Affinity DataKi:  343nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent