BDBM520649 US11147816, Binimetinib (ARRY-162, ARRY-438162)::US11701360, Binimetinib

SMILES Cn1cnc2c1cc(c(c2F)Nc3ccc(cc3F)Br)C(=O)NOCCO

InChI Key InChIKey=ACWZRVQXLIRSDF-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 520649   

LigandPNGBDBM520649(US11147816, Binimetinib (ARRY-162, ARRY-438162) | ...)
Affinity DataIC50: 12nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM520649(US11147816, Binimetinib (ARRY-162, ARRY-438162) | ...)
Affinity DataIC50: 12nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM520649(US11147816, Binimetinib (ARRY-162, ARRY-438162) | ...)
Affinity DataIC50: 12nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)