BDBM520411 (3R,6R,7S,8E,22S)-6′-Chloro-7-methoxy-15,15-dioxo-spiro[[11,20]dioxa[15]thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa[8,16(25),17,19::US11130769, Ex. No. 111

SMILES CO[C@H]1\C=C\COCC(=O)NS(=O)(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=DYZREVKDSJXKLH-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 520411   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM520411(US11130769, Ex. No. 111 | (3R,6R,7S,8E,22S)-6̸...)
Affinity DataKi: <100nMAssay Description:The assay was carried out in black half-area 96-well NBS plate (Corning), containing 15 nM of MCL-1 (BPS Bioscience), 5 nM of FITC-Bim and 3-fold ser...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent