BDBM520409 (3R,6R,8E,22S)-6′-Chloro-7-hydroxy-7-[(4-isopropylpiperazin-1-yl)methyl]-12,12-dimethyl-15,15-dioxo-spiro[11,20-dioxa-15-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16,18,24-tetraene-22,1′-tetralin]-13-one::US11130769, Ex. No. 109

SMILES CC(C)N1CCN(CC2(O)\C=C\COC(C)(C)C(=O)NS(=O)(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)CC1

InChI Key InChIKey=FLOMCNHSTCGGPV-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 520409   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM520409(US11130769, Ex. No. 109 | (3R,6R,8E,22S)-6′-...)
Affinity DataKi: <100nMAssay Description:The assay was carried out in black half-area 96-well NBS plate (Corning), containing 15 nM of MCL-1 (BPS Bioscience), 5 nM of FITC-Bim and 3-fold ser...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent