BDBM520408 (3R,6R,7R,8E,21S)-6′-Chloro-7-methoxy-11-methyl-14,14-dioxo-spiro[19-oxa-14-thia-1,11,13-triazatetracyclo[3.7.2.03,6.018,23]tetracosa-8,15,17,23-tetraene-21,1′-tetralin]-12-one::US11130769, Ex. No. 108

SMILES CO[C@@H]1\C=C\CN(C)C(=O)NS(=O)(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=XDUPOAOTIQMSQX-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 520408   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM520408(US11130769, Ex. No. 108 | (3R,6R,7R,8E,21S)-6̸...)
Affinity DataKi: <100nMAssay Description:The assay was carried out in black half-area 96-well NBS plate (Corning), containing 15 nM of MCL-1 (BPS Bioscience), 5 nM of FITC-Bim and 3-fold ser...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent