BDBM520092 US11142535, Compound 6

SMILES ONC(=O)c1ccc(CN2CCN(CC2)c2ccc(Nc3nc(cn4ccnc34)-c3ccc4cn[nH]c4c3)cc2)cc1

InChI Key InChIKey=JPEJHMDBZXPNMF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 520092   

TargetTyrosine-protein kinase SYK(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM520092(US11142535, Compound 6)
Affinity DataIC50: 10nMAssay Description:Measure of SYK protein kinase activity was carried out by using the Caliper mobility shift assay. The compound was dissolved with DMSO and diluted wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM520092(US11142535, Compound 6)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM520092(US11142535, Compound 6)
Affinity DataIC50: 1.00E+3nMAssay Description:HDAC activity was measured by the Synergy MX Multi-Function Microplate Reader. The compounds were dissolved with DMSO, and transferred to a 384 well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent