BDBM519986 3-((6-((S)-7-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)-3-oxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl)pyridin-3-yl)oxy)benzoic acid::US11142527, Example 16

SMILES COC(=O)C1=C(CN2CCN3[C@H](CN(C3=O)c3ccc(Oc4cccc(c4)C(O)=O)cn3)C2)NC(=N[C@H]1c1ccc(F)cc1Cl)c1nccs1

InChI Key InChIKey=DQYGUYHODDXYNK-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 519986   

TargetLarge envelope protein(HBV-D)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM519986(3-((6-((S)-7-(((R)-6-(2-chloro-4-fluorophenyl)-5-(...)
Affinity DataEC50:  12nMAssay Description:8000 HepG 2.2.15 cells per well were seeded into a 96-well plate, the plate was cultured at 37° C. and 5% CO2 for 3 days till the cells grew to full ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
Go to US Patent