BDBM51935 MLS000911581::N-[3-[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)anilino]-oxomethyl]-5-methoxyphenyl]-5-thiophen-2-yl-3-pyridinecarboxamide;2,2,2-trifluoroacetic acid::N-[3-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]carbamoyl]-5-methoxy-phenyl]-5-thiophen-2-yl-pyridine-3-carboxamide;2,2,2-tris(fluoranyl)ethanoic acid::N-[3-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]carbamoyl]-5-methoxyphenyl]-5-thiophen-2-ylpyridine-3-carboxamide;2,2,2-trifluoroacetic acid::N-[3-[[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]carbamoyl]-5-methoxy-phenyl]-5-(2-thienyl)nicotinamide;2,2,2-trifluoroacetic acid::SMR000718274::US20250195508, Name TL5-134::cid_24816521

SMILES CCN1CCN(Cc2ccc(NC(=O)c3cc(NC(=O)c4cncc(c4)-c4cccs4)cc(OC)c3)cc2C(F)(F)F)CC1

InChI Key InChIKey=CPTHLCALGNOEEX-UHFFFAOYSA-N

Data  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 51935   

LigandPNGBDBM51935(N-[3-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(triflu...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03MH084830-01 Project Title: TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2011
Entry Details
PCBioAssay
LigandPNGBDBM51935(N-[3-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(triflu...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03MH084830-01 Project Title: TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2011
Entry Details
PCBioAssay
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM51935(N-[3-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(triflu...)
Affinity DataIC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay
TargetEphrin type-A receptor 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM51935(N-[3-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(triflu...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM51935(N-[3-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(triflu...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2025
Entry Details
Go to US Patent