BDBM518536 2-Allyl-6-((4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one hydrochloride::US11124518, Example 11::US11299493, Compound 1.4

SMILES CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc4c(CNCC4(C)C)c3)nc12

InChI Key InChIKey=WOBLPQMIMKNCIR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 518536   

TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518536(US11124518, Example 11 | 2-Allyl-6-((4,4-dimethyl-...)
Affinity DataIC50: 10nMAssay Description:Wee 1 kinase was determined by using Flurorescence Resonance Energy Transfer (FRET) assay. In 384-well plates, Wee1 kinase (2 nM final concentration)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518536(US11124518, Example 11 | 2-Allyl-6-((4,4-dimethyl-...)
Affinity DataIC50: 1.60nMAssay Description:IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen Terbium Labeled TR-FRET assay. Kinase assays were performed in 1×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase PLK1(Human)
Emd Serono

Curated by ChEMBL
LigandPNGBDBM518536(US11124518, Example 11 | 2-Allyl-6-((4,4-dimethyl-...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human N-terminal His6-tagged recombinant full-length PLK1 expressed in baculovirus infected Sf9 cells incubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518536(US11124518, Example 11 | 2-Allyl-6-((4,4-dimethyl-...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Recurium Ip Holdings

US Patent
LigandPNGBDBM518536(US11124518, Example 11 | 2-Allyl-6-((4,4-dimethyl-...)
Affinity DataIC50: 44nMAssay Description:Inhibition of WEE1 in human U2OS cells incubated for 1 hr by mesoscale discovery assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed