BDBM518445 US11124500, Example 36::[(2R)-1-[4-[1-(1-Methylazetidin-3-yl)pyrazol-4-yl]-6-(trifluoromethyl)pyrimidin-2-yl]azetidin-2-yl]methanol

SMILES CN1CC(C1)n1cc(cn1)-c1cc(nc(n1)N1CC[C@@H]1CO)C(F)(F)F

InChI Key InChIKey=ZGUZTMBHBWWXLM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518445   

TargetKetohexokinase(Human)
Eli Lilly

US Patent
LigandPNGBDBM518445(US11124500, Example 36 | [(2R)-1-[4-[1-(1-Methylaz...)
Affinity DataIC50: 10nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
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TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Eli Lilly

US Patent
LigandPNGBDBM518445(US11124500, Example 36 | [(2R)-1-[4-[1-(1-Methylaz...)
Affinity DataIC50: 3.98nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent