BDBM518439 1-(3,3-Dimethylpiperazin-1-yl)-2-[4-[2- [(2S)-2-methylazetidin-1-yl]-6- (trifluoromethyl)pyrimidin-4-yl]pyrazol- 1-yl]ethanone::US11124500, Example 31

SMILES C[C@H]1CCN1c1nc(cc(n1)C(F)(F)F)-c1cnn(CC(=O)N2CCNC(C)(C)C2)c1

InChI Key InChIKey=BLDCIJWRIGRMIF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518439   

TargetKetohexokinase(Human)
Eli Lilly

US Patent
LigandPNGBDBM518439(US11124500, Example 31 | 1-(3,3-Dimethylpiperazin-...)
Affinity DataIC50: 34.7nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
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TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Eli Lilly

US Patent
LigandPNGBDBM518439(US11124500, Example 31 | 1-(3,3-Dimethylpiperazin-...)
Affinity DataIC50: 70.5nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent