BDBM518435 6-[1-(3-Hydroxy-4-piperidyl)pyrazol-4-yl]-2-[(2S)-2-methylazetidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile::US11124500, Example 27

SMILES C[C@H]1CCN1c1nc(cc(c1C#N)C(F)(F)F)-c1cnn(c1)C1CCNCC1O

InChI Key InChIKey=BTRMHMJCYJGPJZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518435   

TargetKetohexokinase(Human)
Eli Lilly

US Patent
LigandPNGBDBM518435(US11124500, Example 27 | 6-[1-(3-Hydroxy-4-piperid...)
Affinity DataIC50: 9.21nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
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TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Eli Lilly

US Patent
LigandPNGBDBM518435(US11124500, Example 27 | 6-[1-(3-Hydroxy-4-piperid...)
Affinity DataIC50: 4.63nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent