BDBM518427 2-[4-[5-Cyano-6-[(2S)-2- methylazetidin-1-yl]-4- (trifluoromethyl)-2-pyridyl]pyrazol-1- yl]-N,N-bis(2-hydroxyethyl)acetamide::US11124500, Example 21
SMILES C[C@H]1CCN1c1nc(cc(c1C#N)C(F)(F)F)-c1cnn(CC(=O)N(CCO)CCO)c1
InChI Key InChIKey=ZLHPIMJTCUBOAL-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 518427
Affinity DataIC50: 55.2nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Affinity DataIC50: 39.2nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair