BDBM518426 2-[(2S)-2-Methylazetidin-1-yl]-6-[1- [2-(4-methylpiperazin-1-yl)-2-oxo- ethyl]pyrazol-4-yl]-4- (trifluoromethyl)pyridine-3- carbonitrile::US11124500, Example 20
SMILES C[C@H]1CCN1c1nc(cc(c1C#N)C(F)(F)F)-c1cnn(CC(=O)N2CCN(C)CC2)c1
InChI Key InChIKey=KFBFVOHAXJMGQZ-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 518426
Affinity DataIC50: 150nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Affinity DataIC50: 81.8nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair