BDBM518422 US11124500, Example 16::[(2R)-1-[4-[1-[(3R)-Pyrrolidin-3- yl]pyrazol-4-yl]-6- (trifluoromethyl)pyrimidin-2- yl]azetidin-2-yl]methanol

SMILES OC[C@H]1CCN1c1nc(cc(n1)C(F)(F)F)-c1cnn(c1)[C@@H]1CCNC1

InChI Key InChIKey=RZMSNWAKQJXYMW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518422   

TargetKetohexokinase(Human)
Eli Lilly

US Patent
LigandPNGBDBM518422(US11124500, Example 16 | [(2R)-1-[4-[1-[(3R)-Pyrro...)
Affinity DataIC50: 28nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Eli Lilly

US Patent
LigandPNGBDBM518422(US11124500, Example 16 | [(2R)-1-[4-[1-[(3R)-Pyrro...)
Affinity DataIC50: 30nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent