BDBM518420 (2S,3R)-2-Methyl-1-[4-[1-[(3R)- pyrrolidin-3-yl]pyrazol-4-yl]-6- (trifluoromethyl)pyrimidin-2- yl]azetidin-3-ol::US11124500, Example 14

SMILES C[C@H]1[C@H](O)CN1c1nc(cc(n1)C(F)(F)F)-c1cnn(c1)[C@@H]1CCNC1

InChI Key InChIKey=LGEBDZHNMFGOOZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518420   

TargetKetohexokinase(Human)
Eli Lilly

US Patent
LigandPNGBDBM518420(US11124500, Example 14 | (2S,3R)-2-Methyl-1-[4-[1-...)
Affinity DataIC50: 15.9nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
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TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Eli Lilly

US Patent
LigandPNGBDBM518420(US11124500, Example 14 | (2S,3R)-2-Methyl-1-[4-[1-...)
Affinity DataIC50: 19.1nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent