BDBM518246 US11111247, Example 65::enantiomers

SMILES CN1CC2CCC(N2c2ncc3[nH]nc(-c4cnn(c4)C4CC4)c3n2)C1=O

InChI Key InChIKey=HBAQYPYDRFILMT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 518246   

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM518246(US11111247, Example 65 | enantiomers)
Affinity DataIC50: 1.25E+3nMAssay Description:un-Phosphorylated (UP): The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM518246(US11111247, Example 65 | enantiomers)
Affinity DataIC50: 1.25E+3nMAssay Description:Phosphorylated (P): The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phosphor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM518246(US11111247, Example 65 | enantiomers)
Affinity DataIC50: 2.00E+3nMAssay Description:un-Phosphorylated (UP): The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM518246(US11111247, Example 65 | enantiomers)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of recombinant N-terminal His-Avi-tag human FGFR3 (447 to 761 residues) expressed in Sf9 infected baculovirus expression system using biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM518246(US11111247, Example 65 | enantiomers)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human wild type FGFR1 (399 to 820 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed