BDBM518192 US11111247, Example 22

SMILES COC(=O)N1C[C@H](C)N([C@H](C)C1)c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(C)CC3)c2n1

InChI Key InChIKey=MXDCACLUETVZNL-UHFFFAOYSA-N

Data  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 518192   

TargetHepcidin(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 34nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 213nMAssay Description:Inhibition of recombinant human FGFR2 (400 to 821 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 577nMAssay Description:Inhibition of recombinant human wild type FGFR1 (399 to 820 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 178nMAssay Description:Inhibition of recombinant N-terminal His-Avi-tag human FGFR3 (447 to 761 residues) expressed in Sf9 infected baculovirus expression system using biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 176nMAssay Description:Inhibition of FGFR3 (unknown origin) using peptide substrate incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1 [147-509](Human)
Incyte

US Patent
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 100nMAssay Description:ALK2 (aa 147-end) was obtained from BPS biosciences. The enzymatic assays were conducted in white 384-well polystyrene plates in a final volume of 8 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 901nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 61nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 300nMAssay Description:un-Phosphorylated (UP): The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 1.25E+3nMAssay Description:un-Phosphorylated (UP): The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 300nMAssay Description:un-Phosphorylated (UP): The inhibitor potency of the exemplified compounds was determined in an enzyme discontinuous assay that measures peptide phos...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent

TargetActivin receptor type-1 [147-509](Human)
Incyte

US Patent
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 100nMAssay Description:ALK2 (aa 147-end) was obtained from BPS biosciences. The enzymatic assays were conducted in white 384-well polystyrene plates in a final volume of 8 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent

TargetActivin receptor type-1 [147-509](Human)
Incyte

US Patent
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: 100nMAssay Description:ALK2 (aa 147-end) was obtained from BPS biosciences. The enzymatic assays were conducted in white 384-well polystyrene plates in a final volume of 8 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2022
Entry Details
Go to US Patent