BDBM517799 Preparation of N-(2-((2-(dimethylamino)ethoxy)-5-((4-(4-fluoro-1-isopropyl-2-methoxy-1H-benzo[d]imidazole-6-yl)pyrimidin-2-yl)amino)-4-methoxyphenyl)acrylamide::US11111233, Example 7

SMILES COc1nc2c(F)cc(cc2n1C(C)C)-c1ccnc(Nc2cc(NC(=O)C=C)c(OCCN(C)C)cc2OC)n1

InChI Key InChIKey=KJCNNUJZULRUCH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517799   

TargetEpidermal growth factor receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM517799(US11111233, Example 7 | Preparation of N-(2-((2-(d...)
Affinity DataIC50: 25nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM517799(US11111233, Example 7 | Preparation of N-(2-((2-(d...)
Affinity DataIC50: 1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent