BDBM517797 Preparation of N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-((4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]imidazole[1,2-a]pyrrol-6-yl)pyrimidin-2-yl)amino)-4-methoxyphenyl)acryl amide::US11111233, Example 5

SMILES COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cc(F)c2nc3CCC(C)(C)n3c2c1

InChI Key InChIKey=JIZMRHHYNJWHID-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 517797   

TargetEpidermal growth factor receptor(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM517797(US11111233, Example 5 | Preparation of N-(2-((2-(d...)
Affinity DataIC50: 25nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
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TargetEpidermal growth factor receptor [T790M,L858R](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM517797(US11111233, Example 5 | Preparation of N-(2-((2-(d...)
Affinity DataIC50: 1nMAssay Description:Reagents and Materials:WT EGFR (Carna, Cat. No. 08-115), EGFR [L858R] (Carna, Cat. No. 08-502), EGFR [L858R/T790M] (Carna, Cat. No. 08-510), ATP (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent